Who we are

Autolus is a CAR T cell therapy company. We are applying our extensive programing capabilities to develop advanced autologous T cell therapies that have the potential to deliver life-changing benefits to cancer patients

About us

Obe-cel

The company’s lead therapeutic candidate, obe-cel, is a transformational treatment for adult Acute Lymphoblastic Leukemia. Obe-cel is an autologous CD19 CAR T cell therapy with a unique CD19 CAR. The CAR is designed to have a “fast-off” kinetic which mimics physiological T cell receptor interactions. Clinical trials of obe-cel have demonstrated that this enhanced kinetic profile results in increased T cell persistence leading to high levels of durable remissions and remarkably low levels of cytokine release syndrome and other immunotoxicities. Obe-cel is currently being evaluated in the potentially pivotal FELIX study in adult ALL and in phase 1 studies for other B-NHL indications.

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Our Obe-cel Abstracts and Publications

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American Society of Hematology Annual Meeting
December 13 2021

Safety and Efficacy of AUTO1, a Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (B-NHL) and Chronic Lymphocytic Leukaemia (CLL)

American Society of Hematology Annual Meeting
December 12 2021

Industrialization of an Academic Miltenyi Prodigy-Based CAR T process

Journal of Clinical Oncology
August 04 2021

Durable responses and low toxicity after fast off-rate CD19 CAR-T therapy in adults with relapsed/ refractory B-ALL

Information for patients

Our development programs, including clinical trials, focus on developing safe and efficacious therapies for patients.

Learn more about our CAR T cell therapy clinical trials

Life at Autolus

Whilst working at Autolus you will enjoy a flexible, diverse and dynamic working environment which actively promotes creativity, leadership and teamwork – together we are ONE Autolus.

Careers at Autolus

Investors

Autolus is committed to the development and commercialization of obe-cel in r/r Adult ALL and is progressing opportunities for obe-cel in additional indications alongside its preclinical and clinical pipeline for hematological malignancies and solid tumors.

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