Publication of article in Molecular Therapy describing small molecule-activated off switch which is designed to allow for the selective elimination of T cells programmed to incorporate Caspase 9 (rapaCasp9) using rapamycin (sirolimus, Rapamune®)

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A Dominant Negative SHP-2 Which Abrogates PD-1 Signalling Pathways and Restores Function of Cytotoxic CAR T Cells at the 2017 American Society of Hematology Annual Meeting

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An APRIL based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma has potent activity in vitro and in vivo. Lydia Lee, Benjamin Draper, Neil Chaplin, Brian Philip, Melody Chin, Daria Galas-Filipowicz, Shimobi Onuoha, Simon Thomas, Vania Baldan, Reyisa Bughda, Eva Kokalaki, Dominic Patel, Manuel Rodriguez-Justo, James Francis, Kwee Yong, Martin Pule. Blood

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Targeting T-cell receptor β-constant for immunotherapy of T-cell malignancies. Paul M Maciocia, Patrycja A Wawrzyniecka, Brian Philip, Ida Ricciardelli, Ayse U Akarca, Shimobi C Onuoha, Mateusz Legut, David K Cole, Andrew K Sewell, Giuseppe Gritti, Joan Somja, Miguel A Piris, Karl S Peggs, David C Linch, Teresa Marafioti & Martin A Pule. Nature Medicine 2017 Nov 23; 416–1423 (2017);

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An APRIL Based Chimeric Antigen Receptor to Simultaneously Target BCMA and TACI in Multiple Myeloma (MM) Has Potent Activity in Vitro and in Vivo. Lydia Sarah Hui Lee, Benjamin Owen Draper, Neil Chaplin, Brian Philip, Melody Chin, Daria Galas-Filipowicz, Simon Thomas, Evangelia Kokalaki, James Francis, Kwee L Yong, Martin A Pule. Blood. 2016 Dec 02, 128 (22):379;

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Targeting T-Cell Receptor β-Constant Domain for Immunotherapy of T-Cell Malignancies. Paul Michael Maciocia, Patrycja Wawrzyniecka, Brian Philip, Ida Ricciardelli, Ayse U. Akarca, Shimobi Onuoha, David Cole, Andrew Sewell, Karl S Peggs, David C. Linch, Teresa Marafioti and Martin A Pule. Blood 2016 Dec 02, 128 (22):811;

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A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy. Philip B, Kokalaki E, Mekkaoui L, Thomas S, Straathof K, Flutter B, Marin V, Marafioti T, Chakraverty R, Linch D, Quezada SA, Peggs KS, Pule M. Blood. 2014 Aug 21;124(8):1277-87.

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